Gene Polymorphisms of FGF2 (Rs 1476214) and FGF18 (Rs 4043716) in Non-syndromic Cleft Lip and Palate in Local Population

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Original Article

Author Details : Rasitha V*, Manjunath Hegde, Amarnath BC , Roopak Math ew David, Sharmila Arjunan, Pramod KM

Volume : 2, Issue : 3, Year : 2018

Article Page : 53-58

https://doi.org/10.18231/j.jco.2018.025

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Abstract

Background: Cleft Lip and palate (CLP) are instantly recognizable disruptions of normal facial structure.. Genetic and Environmental factors have a role in aetiology of orofacial clefts. FGFs (Fibroblast Growth Factors) and their receptors (FGFRs) plays an important role in development of craniofacial structures. So this study is done to evaluate the single nucleotide polymorphisms of FGF2 and FGF18 with Non-syndromic cleft lip and palate in local population.
Methodology: 25 subjects with nonsyndromic cleft lip and palate and 25 unrelated controls, collected from the department and the extracted DNA samples were subjected to Polymerase chain reaction and later they were subjected to DNA sequencing. Results were documented
in the form of electropherograms.
Results: The results show strong association between the presence of FGF2 gene variant rs1476214 and FGF18 gene variant rs4043716 with the Nonsyndromic cleft lip and palate. This study also suggests that chances of Non syndromic cleft lip and palate is highest in subjects having GG (p < 0> Conclusion: This study concludes that that FGF2 gene variant rs1476214 and FGF18 gene variant rs4043716 can be considered as one of the genetic marker of Non syndromic cleft lip and palate for our population.
Key words: Non-syndromic Cleft Lip and Palate, FGF2 gene variant rs1476214 and FGF18 gene variant rs4043716.

How to cite : Rasitha V, Hegde M , Amarnath Bc, David R M E, Arjunan S, Pramod Km, Gene Polymorphisms of FGF2 (Rs 1476214) and FGF18 (Rs 4043716) in Non-syndromic Cleft Lip and Palate in Local Population. J Contemp Orthod 2018;2(3):53-58

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