Hypodontia is the congenital absence of one or more teeth and may affect permanent teeth. Depending on the number and position of missing teeth, it may influence aesthetics, mastication, speech, and occlusal equilibrium. Hypodontia therapy includes primary tooth maintenance or space redistribution for partial adhesive bridges, tooth transplantation, and implants. However, an interdisciplinary approach is the most important requirement for the ideal treatment of hypodontia. This case outlines an interdisciplinary treatment strategy for congenitally absent permanent maxillary right lateral incisors, as well as maxillary second premolars and mandibular left second premolar that involves orthodontic and prosthodontic skills.