- Visibility 12 Views
- Downloads 6 Downloads
- Permissions
- DOI doi: 10.18231/j.jco.9402.1758884795
-
CrossMark
A systematic review on the correlation of expression of dentin sialophosphoprotein and orthodontic root resorption: An update on current evidence
- Author Details:
-
Vincy Antony *
-
Anthony George
-
Prathapan Parayaruthottam
-
Muhamed Shaloob
Vincy Antony *
Anthony George
Prathapan Parayaruthottam
Muhamed Shaloob
Objectives: Orthodontic root resorption is a significant concern during orthodontic treatment, and can range from mild (0.4-1.5mm) to severe root resorption (>4mm). Recent studies have suggested that Dentin Sialo phosphoprotein (DSPP) may also be associated with the development and progress of orthodontic root resorption. The current systematic review's objective is to investigate the data currently available about the quantification of DSPP in patients who have orthodontic root resorption.
Materials and Methods: Using both manual and computer databases, a thorough literature search was carried out to find pertinent papers. Primary research studies that explored the association between DSPP expression and orthodontic root resorption in human subjects had been included in the inclusion criteria. The extraction of data and quality appraisal were performed according to established guidelines. A qualitative synthesis of the findings was performed due to variations in study designs and methodologies.
Results: During the initial search, 1192 records were found in total. After the screening procedure, thirty-three papers were chosen for full-text review. Both exclusion and inclusion criteria were used, and twelve studies were ultimately included in this systematic review. Study design, sample size, measuring techniques, and outcome measures varied between the research. DSPP expression and root resorption may be positively correlated, according to some research, although other investigations produced contradictory or equivocal findings.
Conclusions: This systematic review draws attention to the discrepancies in the literature that currently exist on the association between orthodontic root resorption and dentin sialophosphoprotein expression. Methodological differences and limitations across the studies contribute to the inconsistency in findings. The role of DSPP as a predictive marker for root resorption in orthodontic treatment has to be clarified by more studies using bigger sample sizes and standard methods.
References
- Jung YH, Cho BH. External root resorption after orthodontic treatment: a study of contributing factors. Imaging Sci Dent. 2011;41(1):17-21. DOI: 10.5624/isd.2011.41.1.17
[Google Scholar] - McLaughlin KD. Quantitative determination of root resorption during orthodontic treatment. Am J Orthod. 1964;50(2):143. DOI:10.1016/0002-9416(64)90127-7
[Google Scholar] - Lupi JE, Handelman CS, Sadowsky C. Prevalence and severity of apical root resorption and alveolar bone loss in orthodontically treated adults. Am J Orthod Dentofacial Orthop. 1996;109(1):28–
- DOI: 10.1016/s0889-5406(96)70160-9
[Google Scholar] - Levander E, Malmgren O. Evaluation of the risk of root resorption during orthodontic treatment: A study of upper incisors. Eur J Orthod. 1988;10(1):30–8. DOI: 10.1093/ejo/10.1.30
[Google Scholar] - Levander E, Malmgren O, Stenback K. Apical root resorption during orthodontic treatment of patients with multiple aplasia: a study of maxillary incisors. Eur J Orthod. 1998;20(4):427–34. DOI: 10.1093/ejo/20.4.427
[Google Scholar] - Weltman B, Vig KWL, Fields HW, Shanker S, Kaizar EE. Root resorption associated with orthodontic tooth movement: A systematic review. Am J Orthod Dentofac Orthop . 2010;137(4):462–76. DOI: 10.1016/j.ajodo.2009.06.021
[Google Scholar] - Dindaroğlu F, Doğan S. Root Resorption in Orthodontics. Turk J Orthod. 2016;29(4):103–8. DOI: 10.5152/Turk
[Google Scholar] J Orthod.2016.16021. - Roscoe MG, Meira JBC, Cattaneo PM. Association of orthodontic force system and root resorption: A systematic review. Am J Orthod Dentofacial Orthop . 2015;147(5):610 –26. DOI: 10.1016/j.ajodo.2014.12.026
[Google Scholar] - George A, Evans C. Detection of root resorption using dentin and bone markers. Orthod Craniofac Res. 2009;12(3):229–35. DOI: 10.1111/j.1601-6343.2009.01457.x
[Google Scholar] - Sameshima GT, Asgarifar KO. Assessment of root resorption and root shape: periapical vs panoramic films. Angle Orthod. 2001;71(3):185–9. DOI: 10.1043/0003-
[Google Scholar] 3219(2001)071<0185:AORRAR>2.0.CO;2 - Tan JHS, Yazid F, Kasim NA, Ariffin SHZ, Wahab RMA. A newly developed kit for dental apical root resorption detection: efficacy and acceptability. BMC Oral Health. 2024;24(1):298. DOI: 10.1186/s12903-024-04056-5
[Google Scholar] - Khurshid Z, Mali M, Naseem M, Najeeb S, Zafar M. Human Gingival Crevicular Fluids (GCF) Proteomics: An Overview. Dent J. 2017;5(1):12. DOI: 10.3390/dj5010012
[Google Scholar] - Vieira GM. Protein biomarkers of external root resorption: A new protein extraction protocol. Are we going in the right direction? Dent Press J Orthod. 2014;19(6):62–9. DOI: 10.1590/2176-
[Google Scholar] - 6.062-069.oar.
- Mohd Nasri FA, ZainalAriffin SH, Karsani SA, Megat Abdul Wahab R. Label-free quantitative proteomic analysis of gingival crevicular fluid to identify potential early markers for root resorption. BMC Oral Health. 2020;20(1):256. DOI: 10.1186/s12903-020-01246-9
[Google Scholar] - Mah J, Prasad N. Dentine phosphoproteins in gingival crevicular fluid during root resorption. Eur J Orthod. 2004;26(1):25–30. DOI:
- 1093/ejo/26.1.25
- Krishnan V. Root Resorption with Orthodontic Mechanics: Pertinent Areas Revisited. Aust Dent J. 2017;62(S1):71–7. DOI: 10.1111/adj.12483
[Google Scholar] - Yamakoshi Y. Dentin Sialophosphoprotein (DSPP) and Dentin. J Oral Biosci. 2008;50(1):33–44. DOI: 10.2330/joralbiosci.50.33
[Google Scholar] - Butler WT, Bhown M, Brunn JC, D’Souza RN, Farach-Carson MC. et al. Isolation, Characterization and Immunolocalization of a 53- kDal Dentin Sialoprotein (DSP). Matrix. 1992;12(5):343–51. DOI: 10.1016/s0934-8832(11)80030-2
[Google Scholar] - Bronckers ALJJ, Farach-Carson MC, Van Waveren E, Butler WT. Immunolocalization of osteopontin, osteocalcin, and dentin sialoprotein during dental root formation and early cementogenesis in the rat. J Bone Miner Res. 1994;9(6):833–41. DOI: 10.1002/jbmr.5650090609
[Google Scholar] - Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. DOI: 10.1136/bmj.n71
[Google Scholar] - Kereshanan S, Stephenson P, Waddington R,. Identification of dentine sialoprotein in gingival crevicular fluid during physiological root resorption and orthodontic tooth movement. Eur J Orthod. 2008;30(3):307–14. DOI: 10.1093/ejo/cjn024
[Google Scholar] - Balducci L, Ramachandran A, Hao J, Narayanan K, Evans C, George A. Biological markers for evaluation of root resorption. Arch Oral Biol . 2007;52(3):203 -8. DOI: 10.1016/j.archoralbio.2006.08.018
[Google Scholar] - Lombardo L, Carinci F, Martini M, Gemmati D, Nardone M, Siciliani G. Quantitive evaluation of dentin sialoprotein (DSP) using microbeads - a potential early marker of root resorption. Oral Implantol. 2016;9(3):132–42. DOI: 10.11138/orl/2016.9.3.132
[Google Scholar] - Mandour KAA, Tawfeek MA, Montasser MA. Expression of biological markers in gingival crevicular fluid of teeth with orthodontically induced root resorption. J Orofac Orthop Fortschritte Kieferorthopädie. 2021;82(5):313 –20. DOI: 10.1007/s00056-020-00267-x
[Google Scholar] - Uma HL, Nausheer A. Identification of Dentin e Sialophosphoprotein In Gingival Crevicular Fluid To Assess Root Resorption Using Three Piece Base Arch. IOSR J Dent Med Sci (IOSR-JDMS). 2018;17(1):56–63. DOI: 10.9790/0853
[Google Scholar] - - Ghaleb S, Tamish N, ElKenany W, Guindi M. The effect of two different types of forces on possible root resorption in relation to dentin phosphoprotein levels: a single-blind, split-mouth, randomized controlled trial. Prog Orthod. 2021;22(1):44. DOI: 10.1186/s40510-021-00388-y
[Google Scholar] - Huang GY, Choi SH, Jung HD, Kim HS, Hwang CJ, Lee KJ. Tissue- specific biomarkers in gingival crevicular fluid are correlated with external root resorption caused by constant mechanical load: an in vivo study. Clin Oral Investig. 2021;25(11):6321–33. DOI: 10.1007/s00784-021-03932-6
[Google Scholar] - Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366:l4898. DOI: 10.1136/bmj.l4898
[Google Scholar] - Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919. DOI: 10.1136/bmj.i4919
[Google Scholar] 441 Antony et al. / Journal of Contemporary Orthodontics 2025;9(4):429–441 - Baumrind S, Korn EL, Boyd RL. Apical root resorption in orthodontically treated adults. Am J Orthod Dentofacial Orthop. 1996;110(3):311–20. DOI: 10.1016/s0889-5406(96)80016-3
[Google Scholar] - Brezniak N, Wasserstein A. Orthodontically induced inflammatory root resorption. Part I: The basic science aspects. Angle Orthod. 2002;72(2):175–9. DOI: 10.1043/0003-
[Google Scholar] 3219(2002)072<0175:OIIRRP>2.0.CO;2 - Maués CPR, Nascimento RRD, Vilella ODV. Severe root resorption resulting from orthodontic treatment: Prevalence and risk factors. Dent Press J Orthod. 2015;20(1):52–8. DOI: 10.1590/2176-
[Google Scholar] - 1.052-058.oar.
- Makedonas D, Lund H, Gröndahl K, Hansen K. Root resorption diagnosed with cone beam computed tomography after 6 months of orthodontic treatment with fixed appliance and the relation to risk factors. Angle Orthod. 2012;82(2):196–201. DOI: 10.2319/112810-
[Google Scholar] - Samandara A, Papageorgiou SN, Ioannidou-Marathiotou I, Kavvadia-Tsatala S, Papadopoulos MA. Evaluation of orthodontically induced external root resorption following orthodontic treatment using cone beam computed tomography (CBCT): a systematic review and meta-analysis. Eur J Orthod. 2019;41(1):67–79. DOI: 10.1093/ejo/cjy027
[Google Scholar] - Bibi T, Khurshid Z, Rehman A, Imran E, Srivastava KC, Shrivastava D. Gingival Crevicular Fluid (GCF): A Diagnostic Tool for the Detection of Periodontal Health and Diseases. Molecules. 2021;26(5):1208. DOI: 10.3390/molecules26051208
[Google Scholar] - Kapoor P, Chowdhry A, Bagga DK, Bhargava D. Biomarkers in External Apical Root Resorption: An Evidence-based Scoping Review in Biofluids. Rambam Maimonides Med J . 2022;13(4):e0027. DOI: 10.5041/RMMJ.10482
[Google Scholar] - Yamakoshi Y. Dentin Sialophosphoprotein (DSPP) and Dentin. J Oral Biosci. 2008;50(1):33–44. DOI: 10.2330/joralbiosci.50.33
[Google Scholar] - Yuan G, Chen L, Feng J, Yang G, Ni Q, Xu X, et al. Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo. Sci Rep. 2017;7(1):42449. DOI:10.1038/srep42449
[Google Scholar] - Mohd Zain MN, Md Yusof Z, Basri KN, Yazid F, Teh YX, Ashari A. et al. Multivariate versus univariate spectrum analysis of dentine sialophosphoprotein (DSPP) for root resorption prediction: a clinical trial. BMC Oral Health. 2022;22(1):151. DOI: 10.1186/s12903-022-02178-2
[Google Scholar] - Adiwirya MK, Widayati R, Soedarsono N, Anggani H. Concentration of dentin sialoprotein at the initial stage of orthodontic treatment using self-ligating and conventional preadjusted brackets: A pilot study. J Orthod Sci. 2022;11(1):32. DOI: 10.4103/jos.jos_172_21
[Google Scholar] - Owman-Moll P, Kurol J, Lundgren D. Repair of orthodontically induced root resorption in adolescents. Angle Orthod. 1995;65(6):403–8. DOI: 10.1043/0003-
[Google Scholar] 3219(1995)065<0403:ROOIRR>2.0.CO;2 - Sha H, Bai Y, Li S, Wang X, Yin Y. Comparison between electrochemical ELISA and spectrophotometric ELISA for the detection of dentine sialophosphoprotein for root resorption. Am J Orthod Dentofacial Orthop. 2014;145(1):36–40. DOI: 10.1016/j.ajodo.2013.09.008
[Google Scholar]